棘阿米巴是广泛存在于自然环境中、自由生活的致病性阿米巴,可引起人体棘阿米巴性角膜炎(acanthamoeba kerati-tis,AK)[1],在艾滋病等免疫功能低下的人群中还会引起阿米巴性肉芽肿性脑炎、皮肤感染等[2-3]。棘阿米巴原虫包括滋养体和包囊两个阶段,当周围环境不利于生长或受到药物作用时,滋养体就转化为包囊而增强对环境和药物的抵抗能力。因此,临床上有关棘阿米巴感染的治疗效果不理想。阿 Acanthamoeba is a pathogenic amoeba that lives in a natural environment and lives freely. It can cause human acanthamoeba keratitis (AK) [1]. In immunocompromised society such as AIDS The crowd will also cause amebic granulomatous encephalitis, skin infections [2-3]. Acanthamoebla protozoa include trophozoites and cysts in two stages, when the environment is not conducive to growth or by the drug, the trophozoites into cysts and enhance the resistance to the environment and drugs. Therefore, the clinical effect of acanthamoeba infection is not satisfactory. Ah