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以羧甲基壳聚糖为主要原料 ,采用静电脉冲液滴发生器制备了羧甲基壳聚糖离子络合微球。扫描电镜分析结果显示 ,干球粒径约为 10 0μm,粒径分布均匀 ,表面呈多孔结构。微球的溶胀行为对溶液 p H很敏感 ,增大 p H会促进其溶胀 ,溶胀速度和最大溶胀度均有提高。 p H同时影响载药微球的药物释放性能。微球的溶胀性能受到羧甲基壳聚糖溶液浓度、金属离子种类及其浓度等制备条件的影响 ,增大羧甲基壳聚糖溶液浓度或金属离子浓度均能提高最大溶胀度 ,C- Ca微球较 C- Al微球更易溶胀。通过改变 Ca Cl2 溶液浓度 ,初步考察了制备条件对药物释放性能时影响。研究对微球进一步应用于药物释放等领域具有重要意义。
Carboxymethyl chitosan as the main raw material, using electrostatic pulse droplet generator carboxymethyl chitosan ion-complexed microspheres. Scanning electron microscopy analysis showed that the diameter of dry pellets was about 100μm, the particle size distribution was uniform and the surface was porous. The swelling behavior of the microspheres is sensitive to the pH of the solution. Increasing p H will promote the swelling, swelling rate and maximum swelling degree of the microspheres. p H also affects the drug release properties of drug loaded microspheres. The swelling properties of the microspheres are affected by the preparation conditions of the carboxymethyl chitosan solution concentration, the metal ion species and the concentration thereof, and the maximum swelling degree can be increased by increasing the concentration of the carboxymethyl chitosan solution or the metal ion concentration. The C- Ca microspheres swell more easily than C-Al microspheres. By changing the concentration of CaCl 2 solution, the influence of preparation conditions on the drug release performance was investigated. Research on the further application of microspheres in areas such as drug release is of great significance.