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目的 观察急性期和恢复期脑梗死患者血液和脑脊液的神经元特异性烯醇化酶 (neuron-specific enolase,NSE)质量浓度变化 ,探讨其与神经功能缺损程度、脑梗死体积、颅内压以及患者年龄等方面的相关性。方法 该实验采用酶联免疫吸附法 (enzyme-linked immunosorbent assay,ELISA) ,检测观察组 (4 6例 )、对照组 (2 5例 )血液及脑脊液 NSE质量浓度 ,并应用 SPSS1 0 .0统计软件包进行统计学分析。结果 急性脑梗死 (acute cere-bralinfarction,ACI)患者血液和脑脊液 NSE质量浓度显著高于恢复期患者和对照组 (P <0 .0 1 ) ;ACI患者脑脊液 NSE质量浓度显著高于血液 (P <0 .0 1 ) ;血液和脑脊液 NSE质量浓度与梗死体积均呈显著正相关 (P <0 .0 1 ) ,与出院时神经功能缺损程度呈显著正相关 (P <0 .0 1 )。结论 脑脊液或血清中的 NSE质量浓度是脑组织破坏后较合适的生化标记物 ,有助于判断脑梗死患者梗死范围、监测病情变化及疗效观察。
Objective To observe the changes of neuron-specific enolase (NSE) concentration in blood and cerebrospinal fluid (CSF) in patients with acute cerebral infarction and convalescent cerebral infarction, and to investigate the relationship between neuron-specific enolase (NSE) Age and other aspects of the relevance. Methods The enzyme-linked immunosorbent assay (ELISA) was used to detect the concentration of NSE in the blood and cerebrospinal fluid of the observation group (46 cases) and the control group (25 cases). SPSS10.0 statistical software Package for statistical analysis. Results The concentration of NSE in blood and cerebrospinal fluid in patients with acute cerebral infarction (ACI) was significantly higher than that in patients with convalescence and control (P <0.01). NSE concentration in cerebrospinal fluid of ACI patients was significantly higher than that in blood (P < There was a significant positive correlation between the concentration of NSE in blood and cerebrospinal fluid and the volume of infarction (P <0.01), which was positively correlated with the degree of neurological deficit at discharge (P <0.01). Conclusion The concentration of NSE in cerebrospinal fluid (CSF) or serum is a suitable biochemical marker after brain tissue destruction. It is helpful to determine the infarct size of patients with cerebral infarction and to monitor the changes of the disease and the curative effect.