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作者以此革新方案治疗108名侵袭性非何杰金氏淋巴瘤病人。其中男79人,女29人。年龄从小于1岁至60岁以上。病期:Ⅰ期19人,Ⅱ期40人,Ⅲ期22人,Ⅳ期27人。组织学分类:弥漫性低分化型23人,弥漫性混合细胞型10人,弥漫性组织细胞型38人,淋巴母细胞型19人,伯基特淋巴瘤2人,弥漫性未分化型13人,不能分类3人。原发部位:淋巴结71人,Waldeyer扁桃体环及胃肠道20人,骨髓18人,其它淋巴结以外部位17人。治疗方法;静脉推注环磷酰胺600mg/m~2,每周1次,连用8周。第1周和第5周静脉推注阿霉素各1次(50mg/m~2)。静脉推注长春新硷1.4mg/m~2,每周一次,连用8周。每天口服强的松龙40mg/m~2(4周后逐渐减量),连用8周。此连续化疗方案简称Cont-CHOP。
The authors treated 108 invasive non-Hodgkin’s lymphoma patients with this innovative regimen. There are 79 males and 29 females. Ages from less than 1 year to over 60 years old. Disease period: 19 patients in phase I, 40 in phase II, 22 in phase III, and 27 in phase IV. Histological classification: 23 diffusely poorly differentiated types, 10 mixed diffuse cell types, 38 diffuse cell types, 19 lymphoblastic types, 2 Burkitt lymphomas, and 13 diffusely undifferentiated types , can not be classified as 3 people. Primary sites: 71 lymph nodes, 20 Waldeyer tonsillar rings and 20 gastrointestinal tracts, 18 bone marrows, and 17 other sites outside the lymph nodes. Treatment; intravenous injection of cyclophosphamide 600mg/m~2 once a week for 8 weeks. At the first week and the fifth week, doxorubicin was intravenously injected once (50 mg/m~2). Intravenous injection of Changchun Xinhao 1.4mg/m~2 once a week for 8 weeks. Oral prednisolone 40 mg/m 2 daily (decreasing after 4 weeks) for 8 weeks. This continuous chemotherapy regimen is referred to as Cont-CHOP.