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Objective:To study the role and association of functional variations present inFAS gene with idiopathic male infertility.Methods:The case-control study comprised of two groups:160 idiopathic infertile nonobstructive azoospermia patients and200 fertile healthy control men. Genotyping for single-nucleotide polymorphism ofFAS-670A/G(rs1800682) andFAS-1377G/A (rs2234767) was done byPCR-RFLP method.DNA sequencing was used to ascertainPCR-RFLP results.ForFAS-670A/G andFAS-1377G/A functional polymorphism, allele and genotype distribution were evaluated usingChi-square test.Results:Allele and genotype distribution did not differ significantly between patients and controls forFAS-670A/G andFAS-1377 G/A.Conclusions:Human male infertility is a complex disorder and thus other genetic or environmental factors may be contributing to the complex etiology.