前文我们报道了通过 N-乙氧羰甲基亚氨酸酯的烷基化反应合成氨基酸的结果。本文研究在固-液相转移催化条件下,N-氰甲基苯甲亚氨酸酯1的烷基化反应。该反应条件温和,操作简便。烷基化产物不需分离提纯,直接水解即可得到相应的氨基酸。更具有实际意义。 We previously reported the results of the synthesis of amino acids by alkylation of N-ethoxycarbonylmethylimidate. In this paper, the alkylation of N-cyanomethylbenzimidyl ester 1 under solid-liquid phase transfer catalysis was studied. The reaction conditions are mild and easy to operate. Alkylation products without isolation and purification, direct hydrolysis can be the corresponding amino acids. More practical significance.