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利用紫外分光光度法,以“双黄连”中两种主要有效成分:黄芩甙、绿原酸为控制指标,测定“双黄连”注射剂、微型灌肠剂、栓剂的人体血清浓度,并用电子计算机求出三种剂型的AUC、Cmax,Tp及t检验和生物利用度。研究认为“双黄连”栓剂生物利用度优于微型灌肠剂,是“双黄连”注射剂临床静脉滴注后,维持血药浓度的有效剂型。对较轻的患者,则完全可以用“双黄连”栓剂直肠给药,取代“双黄连”注射剂静脉给萄。
Urine spectrophotometry was used to determine the human serum concentrations of Shuanghuanglian injection, microenema, and suppository, using the two main active components in ShuangHuanglian: astragalus and chlorogenic acid as control indicators, and was calculated by an electronic computer. AUC, Cmax, Tp and t tests and bioavailability of the three dosage forms. The study found that “Shuanghuanglian” suppository bioavailability is better than microenema, is “Shuanghuanglian” injection clinical intravenous infusion, maintaining the blood concentration of effective formulations. For the lighter patients, it is entirely possible to use a “Shuanghuanglian” suppository for rectal administration instead of the “Shuanghuanglian” injection for veins.