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目的:探讨尿感方治疗尿路感染的药效。方法:将小鼠随机分为空白对照组、阳性药对照组、模型组、尿感方高、低剂量组(54.29,27.15 g.kg-1)。各组连续ig给药7 d,空白对照组及模型组予同容积蒸馏水,第7天测定其体内抗菌、抗炎作用。将大鼠随机分为空白对照组、阳性药对照组、模型组、尿感方高、低剂量组(38.01,19.01 g.kg-1)。给药方法小鼠,第7天观察其对尿路感染模型大鼠的影响、对大鼠5 h尿量的影响、对大鼠尿分泌型免疫球蛋白a(SIgA)水平的影响。结果:尿感方给药剂量为38.01 g.kg-1时尿感模型大鼠尿菌落计数、肾脏病理等级明显小于模型组(P<0.05);剂量为54.29 g.kg-1时感染小鼠存活率明显高于模型组(P<0.05);剂量分别为54.29,27.15 g.kg-1时致炎小鼠耳肿胀程度明显小于对照组(P<0.01,P<0.05);剂量为38.01 g.kg-1时大鼠5 h尿量及尿SIgA含量明显多于正常组(P<0.01)。结论:尿感方可从抗菌、抗炎、利尿、增强局部免疫等多方面起效,具有治疗尿路感染的作用。
Objective: To investigate the efficacy of urinary flu prescription in treating urinary tract infection. Methods: The mice were randomly divided into blank control group, positive control group, model group, high and low urinary tract group (54.29,27.15 g.kg-1). The rats in each group were administered with ig for 7 days. The blank control group and model group were given the same volume of distilled water, and the antibacterial and anti-inflammatory effects were measured on the 7th day. The rats were randomly divided into blank control group, positive control group, model group, high and low urinary tract group (38.01, 19.01 g.kg-1). The mice were sacrificed on the 7th day to observe the effect on urinary tract infection in rats and the effects of 5-hour urine volume on urinary secretion of immunoglobulin a (SIgA) in rats. Results: The urinary colonies of rats with urinary tract sensitization were significantly lower than those of the model group (P <0.05) at the dose of 38.01 g.kg-1. The mice were infected with the dose of 54.29 g.kg-1 (P <0.05). The ear swelling degree of inflammatory mice was significantly lower than that of the control group (P <0.01, P <0.05) at doses of 54.29 and 27.15 g.kg-1 respectively. The dose was 38.01 g .kg-1 5h urinary output and urine SIgA levels were significantly more than the normal group (P <0.01). Conclusion: The urinary flu prescription can be effective in many aspects such as anti-bacterial, anti-inflammatory, diuretic and local immunization. It has the effect of treating urinary tract infection.