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作者报道3例由卡马西平引起并被迫停药的难治性腹泻病人。例1:女性,38岁,有强直一阵挛发作史3年。去年起出现短暂头痛后头晕发作,每月2～3次,体检及核磁共振检查正常,EEG 示双颞区单一尖波发放,考虑头晕可能为癫痫发作,始服卡马西平(CBZ)200mg/日,一周后增加至600mg/日,起初有短暂的疲乏和倦睡,血清CBZ浓度为6～8μg/ml,服CBZ 后5～7天,出现频繁解大便,6～8次
The authors report three refractory cases of diarrhea caused by carbamazepine and discontinued. Example 1: Female, 38 years old, having an episode of tetanus for 3 years. Last year, a brief headache occurred after the onset of dizziness, 2 to 3 times per month, physical examination and MRI were normal, EEG showed a single spike in the dual temporal region issued to consider dizziness may be seizures, taking carbamazepin (CBZ) 200mg / Day, increased to 600mg / day a week later, initially with brief tiredness and drowsiness, serum CBZ concentration of 6 ~ 8μg / ml, taking CBZ 5 to 7 days after the frequent relief of stool, 6 to 8 times