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为了探讨HBV与肝细胞癌的发病的关系,作者应用原位分子杂交,免疫组化及它们的双标记方法在44例肝癌,17例癌旁肝组织和42例肝硬变的石蜡切片中检测了HBV DNA,HBxAg和HBcAg。研究结果显示,HBV DNA,HBxAg和HBcAg在肝癌组织中的检出率分别为70.5％,65.9％和 20.5％,而在癌旁肝组织内检出率分别为76.5％,76.5％和29.4％,42例肝硬变组织中的检出率分别为88.1％,69.0％和33.3％。本研究中癌周肝组织和肝硬变组织中,HBV DNA,HBxAg和HBcAg的检出率高于肝癌组织,但无统计学意义。本研究结果表明肝细胞肝癌的发生与HBV慢性持续性感染有密切关系。
To investigate the relationship between HBV and hepatocellular carcinoma, the authors used in situ hybridization, immunohistochemistry, and their double labeling methods to detect 44 cases of hepatocellular carcinoma, 17 cases of adjacent liver tissue, and 42 cases of cirrhosis paraffin sections. HBV DNA, HBxAg and HBcAg. The results showed that the detection rates of HBV DNA, HBxAg and HBcAg in hepatocellular carcinoma were 70.5%, 65.9% and 20.5%, respectively, while the detection rates in para-cancer liver tissues were 76.5%, 76.5% and 29.4% respectively. The detection rates in 42 cases of cirrhosis were 88.1%, 69.0% and 33.3%, respectively. In this study, the detection rate of HBV DNA, HBxAg, and HBcAg was higher in cancerous liver tissues and cirrhotic tissues than in liver cancer tissues, but it was not statistically significant. The results of this study indicate that the occurrence of hepatocellular carcinoma is closely related to the chronic persistent infection of HBV.