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为探讨不同程度宫颈病变的细胞核、ＡｇＮＯＲ的变化规律。利用自动图像分析技术分别对２８例宫颈癌，５５例宫颈非典型增生和１５例正常宫颈组织细胞核及ＡｇＮＯＲ颗粒形态定量参数进行测定。结果显示：除正常宫颈与轻度非典型增生宫颈组外，宫颈中度、重度非典型增生与宫颈鳞癌三组之间其平均细胞核面积、每个核ＡｇＮＯＲ颗粒数、平均颗粒面积、颗粒直径以及ＡｇＮＯＲ颗粒面积／细胞核面积之比值逐渐增加，而ＡｇＮＯＲ颗粒形状因子逐渐减小，各组之间存在着统计学差异。ＡｇＮＯＲ颗粒直径变化不显著。认为在宫颈组织发生癌变过程中，细胞核及核内ＡｇＮＯＲ颗粒大小、形态和数量均发生改变。提示细胞核及核内ＡｇＮＯＲ定量参数有可能作为估计肿瘤细胞恶性潜能的指标
To investigate the changes of nucleus and AgNOR in different degrees of cervical lesions. Quantitative parameters of nuclear and AgNOR particles in 28 cases of cervical cancer, 55 cases of atypical hyperplasia of the cervix, and 15 cases of normal cervical tissues were determined by automatic image analysis techniques. The results showed that: In addition to the normal cervical and mild atypical hyperplasia of the cervix group, the average nucleus area, the number of AgNOR particles per particle, the average particle area, and the particle diameter of each nucleus between severe cervical dysplasia and cervical squamous cell carcinoma And AgNOR particle area/nucleus area ratio gradually increased, while AgNOR particle shape factor gradually decreased, there was a statistical difference between the groups. The change in AgNOR particle diameter was not significant. It is believed that in the process of carcinogenesis of cervical tissue, the size, shape and quantity of AgNOR particles in the nucleus and nucleus are changed. Prompt nuclear and nuclear AgNOR quantitative parameters may be used as indicators to estimate the malignant potential of tumor cells