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目的观察不稳定型心绞痛(UA)患者抑郁症的发生情况及路优泰治疗的效果。方法 UA患者315例用汉密尔顿抑郁量表(HAMD)测定其抑郁程度,伴抑郁症患者共86例,随机分为常规治疗组和路优泰治疗组(各43例),8周后观察2组HAMD评分、心绞痛的变化及心脏事件发生情况。结果 UA患者HAMD评分为(13.8±8.5)分,抑郁发生率27.3%,治疗8周后2组HAMD评分均较治疗前降低,且路优泰治疗组治疗后的HAMD评分明显低于常规治疗组(7.9±5.0vs14.2±9.4,P<0.05);心脏事件的发生率稍低于常规治疗组,心绞痛改善有效率稍高于常规治疗组,但差异均无统计学意义(P均>0.05)。结论抑郁症在UA患者中有较高的发病率,对此类患者给予路优泰抗抑郁治疗可改善症状、降低心血管事件的发生。
Objective To observe the incidence of depression in patients with unstable angina (UA) and the effect of Lu You-tai. Methods A total of 86 UA patients with depression and depression were enrolled in this study. 315 patients with depression and depression were randomly divided into routine treatment group and Lu You-tai treatment group (43 cases each). After 8 weeks, two groups were observed. HAMD score, changes in angina and cardiac events. Results The HAMD score of UA patients was (13.8 ± 8.5) points and the incidence of depression was 27.3%. After 8 weeks of treatment, the HAMD scores of both groups were lower than those before treatment, and the HAMD scores of Lu You-tai treatment group were significantly lower than those of conventional treatment group (7.9 ± 5.0 vs 14.2 ± 9.4, P <0.05). The incidence of cardiac events was slightly lower than that of the conventional treatment group, while the improvement of angina pectoris rate was slightly higher than that of the conventional treatment group, but the difference was not statistically significant (P> 0.05 ). Conclusions Depression has a high incidence in UA patients. Antidepressant treatment with Lu You-tai can improve the symptoms and reduce the occurrence of cardiovascular events in these patients.