以 QT校正 ( QTc)延长百分率为效应指标 ,用药代动力学 -药效学 ( PK- PD)结合模型对家犬 iv1 .0 ,2 .0 mg· kg-1的 7- ( 4 -氯苄基 ) - 7,8,1 3,1 3a-四氢小檗碱氯化物 ( CPU860 1 7)后在体内的处置和效应作定量分析 .给家犬 iv CPU860 1 7后的血药浓度经时过程符合二房室模型 ,药物的效应与效应室浓度之间的关系符合 S形 Emax模型 .CPU860 1 7的 PK- PD性质在所用剂量范围内均为非剂量依赖性 . The percentage of QTc prolongation was taken as the effect index, and the pharmacokinetics-pharmacodynamics (PK-PD) combined model was used to evaluate the effect of 7- (4-chlorobenzyl) on iv1.0,0.2 mg · kg- Based on the treatment and effect in vivo after 7,8,1 3,1 3a-tetrahydroberberine chloride (CPU860 1 7) for domestic dogs iv CPU860 1 7 concentration after the passage of time The procedure conformed to a two-compartment model and the relationship between the effect of the drug and the concentration of the effector compartment was in accordance with the S-shaped Emax model.The PK-PD properties of CPU8607 were non-dose-dependent over the dose range used.