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妊娠期肝内胆汁淤积症(ICP)是妊娠中晚期特有的并发症,其发病部位在母体,而主要危害胎儿。ICP发病机制可以从母体和胎儿两个层面来研究,这两个层面有内在联系也有各自病理生理特点,在这两个层面中,分别存在多种因素的作用。母体方面,在一定遗传背景下,雌激素作用通路的异常反应,是研究的主要方向;胎儿方面,胎盘结构和功能改变及其所带来的影响,应成为研究ICP对胎儿危害机制需要关注的重要内容。
Intrahepatic cholestasis of pregnancy (ICP) is a unique complication of the second trimester of pregnancy, the incidence of the site in the maternal, but the main risk to the fetus. The pathogenesis of ICP can be studied from both the maternal and fetal aspects. These two aspects are intrinsically linked and have their own pathophysiological characteristics. In these two aspects, there are a number of different factors. In maternal aspect, the abnormal reaction of estrogen pathway under certain genetic background is the main direction of research. In terms of fetus, the change of placental structure and function and its impact should be the focus of research on the mechanism of ICP on fetal harm important content.