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目的分析2000-2011年中国30岁以上人群膳食胆固醇摄入量对心肌梗死发病的影响。方法在“中国健康与营养调查”中,选取2000年起加入研究队列时30岁以上、未被诊断过心肌梗死且2004-2011年四次追访中至少参加一轮调查的5 434人作为研究对象。采用Cox比例风险模型估计膳食胆固醇摄入量对心肌梗死发病的相对危险度。结果研究对象基线平均年龄为(49.2±12.1)岁,共追访51 372.5人年,平均追访9.5年,其中127人发病。分性别拟合回归模型发现,调整年龄、生活方式、社会经济地位及其他慢性病等混杂因素后,无论基线胆固醇摄入量、累积平均胆固醇摄入量或依时间变化的胆固醇摄入量均未发现与心肌梗死的发病有显著关联。结论此研究认为膳食胆固醇摄入量增加并不是心肌梗死发病的危险因素,两者可能无关。
Objective To analyze the effect of dietary cholesterol intake on the incidence of myocardial infarction in Chinese population over the age of 30 from 2000 to 2011. Methods In the “China Health and Nutrition Surveys”, we selected 5 434 people who were over 30 years old when they joined the research cohort since 2000, who had not been diagnosed with myocardial infarction and participated in at least one round of interviews during the four follow-up visits in 2004-2011 As research target. Cox proportional hazards model was used to estimate the relative risk of dietary cholesterol intake to the incidence of myocardial infarction. Results The average baseline age at study was (49.2 ± 12.1) years. A total of 51 372.5 person-years were interviewed, with an average of 9.5 years of follow-up, of which 127 were reported. The gender-fitting regression model found no differences in baseline cholesterol intake, cumulative mean cholesterol intake, or cholesterol intake over time after adjustment for age, lifestyle, socioeconomic status, and other chronic conditions Significantly associated with the incidence of myocardial infarction. Conclusions This study suggests that increased dietary cholesterol does not appear to be a risk factor for the development of myocardial infarction, both of which may not.