胃癌的发生发展是一个涉及多基因、多分子水平的多阶段过程．目前，文献报道癌基因产物的检测，多数针对某单一癌基因的变化，其结果可比性较差，结论常常不一致．我们采用免疫组化方法，从胃癌的连续切片中同步检测ｐ５３，ｐ２１ｒａｓ，ＣｅｒｂＢ２和癌胚抗原（ＣＥＡ The occurrence and development of gastric cancer is a multi-stage process involving multiple genes and multiple molecules. At present, the literature reports on the detection of oncogene products, most of which focus on the changes of a single oncogene. The results are less comparable and the conclusions are often inconsistent. We used immunohistochemistry to simultaneously detect p53, p21ras, CerbB2 and carcinoembryonic antigen (CEA) from serial sections of gastric cancer.