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目的观察脂微球前列腺素E1治疗慢性肾功能不全的疗效。方法将70例慢性肾功能不全患者随机分为治疗组和对照组各35例,对照组给予一般对症治疗,治疗组在同对照组治疗的基础上给予脂微球前列腺素E1,观察两组患者治疗前后的血尿素氮、肌酐、血尿酸、24h尿蛋白定量、血红蛋白、血压等指标,并观察临床症状的变化。结果两组治疗前后血尿素氮、肌酐、尿酸均有明显变化,但治疗组作用尤为明显,差异均有统计学意义(均P<0.05);24h尿蛋白定量治疗组下降显著(P<0.05),对照组则不明显(P>0.05);血红蛋白、平均动脉压两组治疗前后都有不同程度的改善,但差异均无统计学意义(均P>0.05)。结论脂微球前列腺素E1对慢性肾功能不全患者有一定的治疗作用。
Objective To observe the therapeutic effect of lipid microsphere prostaglandin E1 on chronic renal insufficiency. Methods Seventy patients with chronic renal insufficiency were randomly divided into treatment group and control group, 35 cases in each group. The control group was given symptomatic treatment. The treatment group was given Lipofectamine prostaglandin E1 on the basis of the control group. Before and after treatment of blood urea nitrogen, creatinine, serum uric acid, 24h urinary protein, hemoglobin, blood pressure and other indicators, and observe the changes in clinical symptoms. Results Before and after treatment, blood urea nitrogen, creatinine and uric acid had significant changes, but the effect of treatment group was more obvious (all P <0.05); the level of 24h urine protein decreased significantly (P <0.05) (P> 0.05). Hemoglobin and mean arterial pressure were improved in both groups before and after treatment, but the difference was not statistically significant (all P> 0.05). Conclusion Lipopeptide prostaglandin E1 has a certain therapeutic effect on patients with chronic renal failure.