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在残基252-287之间,血小板膜糖蛋白(GP)Ib-Ⅸ-Ⅴ的GPⅠba受体复合物携带着血管性假性血友病因子(vWF)结合位点。这个位置氨基末端的亮氨酸多重复区(leucine rich repeats,LRR)包含一个苏氨酸145蛋氨酸(Thr145Met)多态性现象,与人类血小板抗原(HPA)-2系统相关。为了研究这个突变的影
Between residues 252-287, the GPIba receptor complex of platelet glycoproteins (GP) Ib-IX-V carries a von Willebrand factor (vWF) binding site. The amino-terminal leucine rich repeats (LRRs) at this site contain a Thr 145 Met polymorphism linked to the human platelet antigen (HPA) -2 system. In order to study the shadow of this mutation