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[目的]探讨血清微小 RNA133(miRNA-133)、人附睾蛋白4(HE4)、血红素氧合酶 1(HO-1)与慢性心力衰竭(CHF)患者心功能的相关性.[方法]选取 2016 年 10 月至 2017 年 8 月本院收治的 140 例 CHF患者(观察组)的临床资料,另选取同期 70 例健康体检者为对照组.检测并比较两组血清 miRNA-133、HE4、HO-1 水平,并分析 miRNA-133、HE4、HO-1 水平与 CHF 患者 LVEF 相关性.[结果]观察组血清 HE4、HO-1、miRNA-133 水平均显著的高于对照组,差异具有统计学意义(P <0.05).CHF患者血清 HE4、HO-1、miRNA-133 水平随着 NYHA分级增加逐渐升高,组间比较差异均有统计学意义(P <0.05).观察组血清HE4、HO-1 、miRNA-133 水平与 CHF 患者 LVEF 均呈显著负相关性(rHE4 =-0.6 1 1 ,rHO-1 =-0.628, rmiRNA-133=-0.702,均P <0.05).[结论]CHF 患者 miRNA-1 33、HE4、HO-1 表达明显上升,同时 miRNA-133、HE4、HO-1 的表达与CHF患者的心功能呈显著负相关性.“,”[Obj ective]To investigate the correlation between serum microRNA1 33 (microRNA1 3 3 ),hu-man epididymal protein 4 (HE4),heme oxygenase 1 (HO-1 )and cardiac function in patients with chronic heart failure (CHF).[Methods]The clinical data of 140 patients with CHF (observation group)admitted to our hospital from October 201 6 to August 2017 were selected,and 70 healthy persons in the same period were selected as the control group.Serum levels of microRNA133,HE4 and HO-1 were detected and compared be-tween the two groups,and the correlation between microRNA133,HE4 and HO-1 levels and LVEF in CHF patients was analyzed.[Results]The serum HE4,HO-1 and microRNA-1 33 levels in the observation group were significantly higher than those in the control group (P <0.05).Serum HE4,HO-1 and microRNA-133 levels in CHF patients gradually increased with the increase of NYHA classification,and there were significant differences between groups (P <0.05).Serum HE4,HO-1 and microRNA133 levels in the observation group were negatively correlated with LVEF in CHF patients (rHE4=-0.61 1 ,rHO-1=-0.628,rmiRNA-133=-0.702 mean P <0.05 ).[Conclusion]The expression of microRNA-133,HE4 and HO-1 increases significantly in CHF patients,while the expression of microRNA-1 33 ,HE4 and HO-1 is negatively correlated with cardiac function in CHF patients.