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环磷酸腺苷(cAMP)和环磷酸鸟苷(cGMP)广泛地存在于一切生物细胞中,在许多情况下互相拮抗。细胞增殖与否可能主要决定于cAMP 和cGMP 的含量和/或cAMP/cGMP 的比值。许多实验表明恶性肿瘤的发生与cAMP 和cGMP 含量的变化有关。本文对急性白血病时cGMP 及cAMP/cGMP 比值变化进行了初步研究。作者观察到急性白血病人不仅白细胞而且血浆环核苷酸也有相应的改变,表明血浆的变化能反映出白细胞内环核苷酸水平。通过血浆测定以了解白
CAMP and cGMP are widely found in all living cells and in many cases antagonize each other. Cell proliferation or not may be mainly determined by cAMP and cGMP content and / or cAMP / cGMP ratio. Many experiments show that the occurrence of malignant tumors and cAMP and cGMP content changes. In this paper, the acute leukemia cGMP and cAMP / cGMP ratio changes were studied. The authors observed not only white blood cells in patients with acute leukemia and plasma cyclic nucleotide nucleotides also have corresponding changes, indicating that changes in plasma reflect the white blood cell nucleotides levels. Through the plasma test to understand the white