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目的探讨脑血管血液动力学指标 (CVHI)和卒中危险因素与卒中发病风险的关系。方法用巢式病例对照研究设计 ,选择东北等地区队列人群中新发生的 4 5 9例卒中患者及随机选取同等数量的对照组 ,估计 CVHI积分值降低和卒中常见危险因素暴露与卒中发病的风险。结果单因素分析显示 :CVHI、高血压、心脏病、糖尿病、卒中家族史、高血压病家族史、饮酒史和吸烟史的优势比 (OR值 )分别为 3.89、2 .83、1.5 5、1.5 6、1.85、1.75、1.2 8和 1.36 ,除糖尿病史和饮酒史外 ,其余因素与卒中均有显著的病因学联系 (P<0 .0 5 ) ,CVHI积分值的降低与卒中发病风险增加具有显著的剂量反应关系。多因素 L ogistic回归分析显示 ,被筛选进入方程的因素分别为 :CVHI积分、高血压病史、卒中家族史和吸烟。结论脑血液动力学积分值降低、高血压病史、卒中家族史和吸烟是卒中的独立危险因素 ,CVHI积分值与卒中风险具有显著的剂量反应关系。
Objective To investigate the relationship between cerebrovascular hemodynamic parameters (CVHI) and stroke risk factors and the risk of stroke. Methods A nested case-control study was designed. A total of 459 stroke patients in the cohort of northeastern China and other randomly selected control groups were enrolled in this study. The reduction of CVHI score and the risk of exposure to stroke and risk of stroke were estimated . Results Univariate analysis showed that odds ratios (OR) of CVHI, hypertension, heart disease, diabetes, family history of stroke, family history of hypertension, alcohol drinking history and smoking history were 3.89, 2.83, 1.55 and 1.5 6,1.85,1.75,1.28 and 1.36, except for the history of diabetes and alcohol consumption, other factors and stroke were significantly etiological (P <0. 05), CVHI integral value decreased with the risk of stroke with Significant dose response relationship. Multivariate L ogistic regression analysis showed that the factors screened into the equation were: CVHI score, history of hypertension, family history of stroke, and smoking. Conclusions The lower integral of cerebral hemodynamics, history of hypertension, family history of stroke and smoking are independent risk factors for stroke. CVHI score has a significant dose response relationship with stroke risk.