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探讨肝硬化患者血清血小板生成素(TOP)浓度与血小板减少的关系。用酶联免疫吸附法(ELISA)测定肝硬化肝功能代偿期、失代偿期以及正常人血清TPO浓度。血清TOP浓度正常人、肝硬化肝功能代偿期、失代偿期分别为(136.24±68.56)pg.m l-1、(124.34±41.31)pg.m l-1和(59.05±52.77)pg.m l-1。肝硬化肝功能失代偿期的血清TPO浓度较正常人明显降低(t=4.04,P<0.001);正常人的血清TPO浓度受外周血小板计数的调节,而肝硬化患者的血清TPO浓度与外周血小板计数之间无明显相关而与血清白蛋白浓度呈正相关(r=0.86,P<0.001)、血清总胆红素浓度呈负相关(r=0.49,P<0.05)。肝细胞产生TPO不足可能是肝硬化发生血小板减少的主要原因。血清TPO浓度可能是评价肝硬化患者肝功能的有用指标。
To investigate the relationship between serum thrombopoietin (TOP) and thrombocytopenia in cirrhotic patients. Enzyme-linked immunosorbent assay (ELISA) was used to determine liver function decompensation, decompensation and normal serum TPO concentration in patients with cirrhosis. The serum TOP concentration of normal people, liver cirrhosis decompensated and decompensated were (136.24 ± 68.56) pg.m l-1, (124.34 ± 41.31) pg.m l-1 and (59.05 ± 52.77) pg .m l-1. The level of serum TPO in cirrhotic patients with decompensated liver function was significantly lower than that in healthy people (t = 4.04, P <0.001). The serum TPO level in normal people was regulated by peripheral platelet count. However, There was no significant correlation between platelet count and serum albumin concentration (r = 0.86, P <0.001), and serum total bilirubin concentration was negatively correlated (r = 0.49, P <0.05). Lack of TPO in liver cells may be the main reason for thrombocytopenia in cirrhosis. Serum TPO levels may be useful indicators of liver function in patients with cirrhosis.