论文部分内容阅读
目的探讨PCF方案与FOLFOX4方案治疗进展期胃癌(AGC)的疗效及安全性。方法 94例AGC患者根据不同化疗方案分为两组。A组,49例,PCF方案:PTX 35～50mg/m2,3h静滴,第1、8、15天;5-FU 750mg/m2,持续静滴,第1～5天;DDP 20mg/m2,2h静滴,第1～5天。B组,45例,FOLFOX4方案:草酸铂85mg/m2,静脉滴注2h,第1天;亚叶酸钙200mg/m2,静滴2h,第1、2天;氟脲嘧啶400mg/m2,静注,第1、2天,氟脲嘧啶600mg/m2,持续静脉泵输注22h,第1、2天。每4周为1疗程,疗程后评判近期疗效、安全性,持续随访远期疗效。结果 A组总有效率(ORR)46.9%,疾病控制率(DCR)81.6%,中位生存期(MST)10.6个月,1年生存率35.0%;B组ORR 46.7%,DCR 82.2%,MST 9.8个月,1年生存率33.1%;两组近、远期疗效差异无统计学意义(P>0.05)。Ⅲ～Ⅳ度不良反应主要为中性粒细胞减少、恶心呕吐。A组脱发发生率高于B组,外周神经毒性低于B组(P<0.05)。结论 PCF方案与FOLFOX4方案治疗AGC,疗效和生存情况相似,不良反应均可耐受。
Objective To investigate the efficacy and safety of PCF and FOLFOX4 in the treatment of advanced gastric cancer (AGC). Methods 94 patients with AGC were divided into two groups according to different chemotherapy regimens. A group, 49 cases, PCF program: PTX 35 ~ 50mg / m2, 3h intravenous drip, the 1st, 8th and 15th days; 5-FU 750mg / 2h intravenous infusion, the first 1 to 5 days. Group B, 45 cases, FOLFOX4 program: oxaliplatin 85mg / m2, intravenous infusion of 2h, the first day; leucovorin 200mg / m2, intravenous drip 2h, days 1,2; fluorouracil 400mg / m2, intravenous injection , 1,2 days, fluorouracil 600mg / m2, continuous intravenous infusion of 22h, day 1,2. Every 4 weeks for a course of treatment, evaluation of the recent course of treatment efficacy, safety, follow-up long-term efficacy. Results The total effective rate (OR) was 46.9%, the disease control rate (DCR) was 81.6%, the median survival time was 10.6 months and the 1-year survival rate was 35.0% in group A, 46.7% in group B, 82.2% in DCR, 9.8 months, 1-year survival rate was 33.1%; There was no significant difference between the two groups in long-term and long-term efficacy (P> 0.05). Ⅲ ~ Ⅳ degree of adverse reactions are mainly neutropenia, nausea and vomiting. The incidence of hair loss in group A was higher than that in group B, and the peripheral neurotoxicity was lower in group A than in group B (P <0.05). Conclusions PCF regimen and FOLFOX4 regimen are similar to AGC in curative effect and survival, and adverse reactions can be tolerated.