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目的探讨p27Kip1(CDKN1B,以下简称p27)基因V109G多态性与乳腺癌易感性的关系。方法检索Med-line、Pubmed、Web of Science和CNKI数据库,获取p27基因V109G多态性与乳腺癌易感性的相关研究,以病例组和对照组p27基因V109G基因型分布的比值比(OR)为效应指标,确定纳入标准,对文献进行评价筛选和异质性检验,用Meta分析软件对各研究原始结果进行统计处理,计算合并OR值及95%可信区间。结果按照纳入标准共入选3篇文献,累计病例1853例,对照病例1516例,Meta分析结果显示合并OR值为0.95(95%可信区间:0.82～1.12,Z值为0.58)。结论以目前相关研究结果的Meta分析显示,p27基因V109G基因多态性与乳腺癌易感性之间不存在相关性,即p27基因V109G多态性不影响个体患乳腺癌的风险。
Objective To investigate the relationship between the V109G polymorphism of p27Kip1 (CDKN1B, hereinafter referred to as p27) and susceptibility to breast cancer. Methods The relationship between the V109G polymorphism of p27 gene and the susceptibility to breast cancer was obtained by searching Med-line, Pubmed, Web of Science and CNKI databases. The odds ratio (OR) of V109G genotype distribution between cases and controls was Effect indicators, determine the inclusion criteria, evaluation of the literature screening and heterogeneity test, Meta analysis software to calculate the original results of each study, calculate the combined OR and 95% confidence interval. Results According to the inclusion criteria, 3 articles were selected. There were 1853 cumulative cases and 1516 control cases. Meta analysis showed that the combined OR was 0.95 (95% CI: 0.82-1.12, Z = 0.58). Conclusion Based on the current meta-analysis of relevant research results, there is no correlation between V109G polymorphism of p27 gene and susceptibility to breast cancer, that is, the V109G polymorphism of p27 gene does not affect the risk of breast cancer in individuals.