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目的 为减少羧基类长效血管紧张素转换酶抑制剂 (ACEI)致咳嗽的副作用。方法 我们对 1995年 1月至 1999年 3月 70 5例服用 ACEI者与 30 6例服用长效二氢吡啶类钙拮抗剂 (CCB)的高血压病患者进行对比研究。结果 发现 ACEI组咳嗽发生率为 15 % ,明显高于 CCB组。结论 咳嗽的发生与年龄、性别无关 ,与 ACEI的剂量增加、肾功能损害有关。联合用药不仅降压效果好 ,而且咳嗽副作用明显减少。
The purpose is to reduce the side effects of cough caused by carboxy-type long-acting angiotensin-converting enzyme inhibitor (ACEI). Methods We compared 705 hypertensive patients with ACD treated with 30 6 long-acting dihydropyridine calcium antagonists (CCB) from January 1995 to March 1999. The results showed that the incidence of cough in ACEI group was 15%, significantly higher than the CCB group. Conclusion The occurrence of cough has nothing to do with age and sex, and is related to the dose of ACEI and the impairment of renal function. Combined antihypertensive effect is not only good, but also significantly reduced cough side effects.