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作者复习了1980年～1992年的自出生至17岁骨髓移植的全部病例。67例中有10例并发慢性阻塞性肺疾病综合征,其中7例有一次或多次HRCT检查。从骨髓移植至诊断阻塞性肺疾病(OLD)的平均时间是11个月(5～31个月)。症状包括咳嗽(7例),呼吸困难(5例),哮喘(4例)和咯痰(3例)。临床诊断OLD至初次HRCT的平均时间3个月(0～60个月)。 全部病例均做了胸片和肺功能检查。结果均符合OLD。3例做了组织学和细菌学分析,活检示限局性或弥漫性间质纤维化,伴有间质和支气管的淋巴
The authors reviewed all cases of bone marrow transplants from birth to the age of 17 from 1980 to 1992. Of the 67 patients, 10 had chronic obstructive pulmonary disease syndrome, of which 7 had one or more HRCT examinations. The average time from bone marrow transplantation to diagnosis of obstructive pulmonary disease (OLD) was 11 months (range, 5 to 31 months). Symptoms include cough (n = 7), dyspnea (n = 5), asthma (n = 4) and expectoration (n = 3). The mean time from clinical diagnosis of OLD to primary HRCT was 3 months (0 to 60 months). All cases were done chest X-ray and pulmonary function tests. Results are in line with OLD. Histological and bacteriological analyzes were performed in 3 cases. Biopsies showed limited or diffuse interstitial fibrosis with lymph nodes associated with stroma and bronchi