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中国食管癌高发区河南省近１５年（１９８０～１９９４）病理确诊的７３６４例食管癌中，其中食管原发性腺癌（ＰＥＡ）２３９例，占３．２５％。通过对２３９例ＰＥＡ手术标本（包括早期癌２０例，其余为中、晚期癌）切片系统观察，指出中国食管癌高发区ＰＥＡ主要起源于食管固有腺体的各级导管部分。ＰＥＡ的病理组织学可分６型：腺导管癌（１０９例）、腺鳞癌（５４例）、腺样囊性癌（２９例）、粘液表皮样癌（２０例）、基底细胞样癌（１５例）、胃型腺癌（１２例）。每型的组织图象及预后均各有特点，提示ＰＥＡ组织学再分型有意义。
Of the 7,364 cases of esophageal cancer diagnosed in Henan Province, a high-incidence area of esophageal cancer in China in the past 15 years (1980-1994), 239 were primary esophageal adenocarcinomas (PEA), accounting for 3.25%. Through observation of 239 surgical specimens of PEA (including 20 cases of early cancer and the rest of them were middle and late cancers), it was pointed out that the PEA in the high-incidence area of esophageal cancer in China mainly originated from the various levels of the ducts of the esophageal glands. The histopathology of PEA can be divided into 6 types: adenocarcinoma (109 cases), adenosquamous carcinoma (54 cases), adenoid cystic carcinoma (29 cases), mucoepidermoid carcinoma (20 cases), basal cell carcinoma ( 15 cases) and gastric adenocarcinoma (12 cases). The histological images and prognosis of each type have their own characteristics, suggesting that PEA histological subtyping is significant.