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本文用阳离子化牛血清白蛋白制作大鼠原位性肾炎模型，观察血栓素Ａ＿２前列环素平衡的变化及与肾小球病理变化的关系。将模型动物随机分成２组，分别腹腔内注射Ｄａｚｏｘｉｂｅｎ、蒸馏水，共注射２周。结果显示，大鼠免疫２周后，肾皮质ＴＸＢ＿２升高，６－Ｋｅｔｏ－ＰＧＦ＿１α降低，尿蛋白量增加。４周后上述改变加重伴血小板聚集强度增大。治疗组大鼠肾皮质ＴＸＢ＿２降低，６－Ｋｅｔｏ－ＰＧＦ＿１α升高，ＴＸＢ＿２／６－Ｋｅｔｏ－ＰＧＦ＿１α比值降低，血小板聚集强度减弱，肾小球足突融合部分缓解，ＧＢＭ中电子致密物有溶解吸收迹象。统计处理提示，尿蛋白与ＴＸＢ＿２呈正相关（ｒ＝０．７８４４），与６－Ｋｅｔｏ－ＰＧＦ＿１α呈负相关（ｒ＝－０．７１６３）。表明原位性肾炎大鼠肾皮质存在着ＴＸＡ＿２－ＰＧＩ＿２平衡失调，肾小球病理变化与ＴＸＡ＿２－ＰＧＩ＿２平衡失调有关。
In this paper, cationized bovine serum albumin rat model of ankylosing kidney in order to observe the change of thromboxane A 2 prostacyclin balance and glomerular pathological changes. The model animals were randomly divided into two groups, respectively, intraperitoneal injection of Dazoxiben, distilled water, a total of 2 weeks. The results showed that after 2 weeks of immunization, TXB_2 in renal cortex increased, while 6-Keto-PGF_1α decreased and urine protein increased. After 4 weeks, the above changes aggravate with increased platelet aggregation intensity. In the treatment group, TXB_2 decreased, 6-Keto-PGF_1α increased, the ratio of TXB_2 / 6-Keto-PGF_1α decreased, the platelet aggregation intensity decreased, glomerular foot process fusion partially alleviated, and GBM electron- . Statistical analysis suggested that urinary protein was positively correlated with TXB_2 (r = 0.7844) and negatively correlated with 6-Keto-PGF_1α (r = -0.7163). TXN 2 -PGI 2 imbalance was observed in renal cortex of rats with nephritis in situ. The pathological changes of glomeruli were related to the imbalance of TXA 2 -PGI 2.