有报道,用阿片受体拮抗剂外周或中枢给药,有助于内毒素性或失血性休克的恢复,并能增加动物休克后的存活率,提示阿片肽参与休克的病理生理过程。本研究是用失血性休克大鼠,侧脑室内注射阿片受体拮抗剂和阿片肽的抗血清,观察对心血管活动的影响。 戊巴比妥钠(50 mg/kg)麻醉大鼠(200～300g,)。经左侧颈总动脉插管,记录平均动脉血压(MAP),并连接于恒压瓶,放血至45 mmHg,维持 It has been reported that administration of peripheral or central opioid receptor antagonists is helpful for the recovery of endotoxin or hemorrhagic shock and can increase the survival rate after shock, suggesting that opioid peptide is involved in the pathophysiology of shock. This study used hemorrhagic shock rats, lateral ventricle opioid receptor antagonist and opioid antiserum to observe the impact on cardiovascular activity. Rats were anesthetized with sodium pentobarbital (50 mg / kg) (200-300 g). The left common carotid artery cannulation, recording mean arterial pressure (MAP), and connected to the constant pressure bottle, bleeding to 45 mmHg, to maintain