头孢哌酮(cefoperazone)是第三代头孢菌素,体外有极强的抗伤寒杆菌活性,在胆道中浓度高.作者用氯霉素与头孢哌酮进行儿童重型伤寒的治疗对照研究。研究对象25例均为海地大学儿科住院儿童,年龄2～15(平均8.6)岁。所有患儿持续发热超过39℃(肛温)5天或5天以上,伴有伤寒的中毒症状,无其它感染的症状或体征,血培养阳性。合并其他细菌感染、不耐受头孢菌素类治疗及过敏者除外。采用随 Cefoperazone (cefoperazone) is the third generation cephalosporin, in vitro has a strong anti-typhoid activity, high concentration in the bile duct. The author of chloramphenicol and cefoperazone for children with severe typhoid treatment control study. All 25 subjects were children hospitalized in Haiti University, ranging in age from 2 to 15 (average 8.6 years). All children with persistent fever over 39 ℃ (rectal temperature) for 5 days or more, accompanied by symptoms of typhoid fever, no other signs or symptoms of infection, blood culture positive. Combined with other bacterial infections, intolerance cephalosporins treatment and allergies were excluded. With