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目的 :从临床角度结合冠状动脉造影结果分析不同类型冠心病 (CHD)患者血清C 反应蛋白 (CRP)和白细胞介素 6 (IL 6 )浓度差异 ,探讨炎症反应及冠状动脉狭窄程度在CHD发生发展中的作用以及两者的相互关系。方法 :检测 13例急性心肌梗死 (AMI)患者 (AMI组 )、4 0例不稳定型心绞痛患者 (UAP组 )、32例稳定型心绞痛患者 (SAP组 )以及 6 2例正常者 (对照组 )血清CRP、IL 6浓度 ,并结合冠状动脉狭窄程度分析不同类型CHD患者血清CRP和IL 6浓度差异 ,对血清CRP、IL 6及冠状动脉病变积分进行相关分析。结果 :CHD组患者血清CRP、IL 6显著高于对照组 [(5 .0 8± 2 .4 4 )∶(2 .32± 1.2 3)mg L、(15 .5 1± 3.5 4 )∶(11.5 6± 3.2 8)ng L],均P <0 .0 1。AMI组与UAP组间血清CRP、IL 6比较差异均无显著性意义 (P >0 .0 5 ) ,但均显著高于SAP组 (P <0 .0 5 ) ,SAP组血清CRP、IL 6均显著高于对照组 (P <0 .0 5 )。血清CRP与IL 6显著性相关 (r =0 .5 5 ,P <0 .0 1)。血清CRP、IL 6分别与冠状动脉病变积分显著性相关 ,相关系数分别为 0 .5 7和 0 .4 3,均 P <0 .0 1。结论 :不同类型CHD患者炎症反应水平不同 ,冠状动脉病变越广泛 ,血清CRP、IL 6水平增高越多 ,血清CRP、IL 6增高可能是CHD的重要危险因素
OBJECTIVE: To analyze the difference of serum C-reactive protein (CRP) and interleukin-6 (IL-6) levels in patients with different types of coronary heart disease (CHD) from a clinical perspective in combination with coronary angiography to investigate the relationship between the inflammatory response and the severity of coronary artery stenosis In the role and the relationship between the two. Methods: Thirteen patients with acute myocardial infarction (AMI), 40 patients with unstable angina (UAP), 32 patients with stable angina (SAP) and 62 normal controls (control group) Serum levels of CRP and IL-6, and the degree of coronary stenosis were analyzed in patients with different types of CHD serum concentrations of CRP and IL-6, serum CRP, IL 6 and coronary artery disease score related analysis. Results: The serum levels of CRP and IL-6 in CHD group were significantly higher than those in control group [(5.08 ± 2.44) :( 2.32 ± 1.2 3) mg L, (15.5 ± 3.54) 11.5 6 ± 3.2 8) ng L], all P <0. Serum levels of CRP and IL-6 in AMI group and UAP group had no significant difference (P> 0.05), but both were significantly higher than those in SAP group (P <0. 05) Were significantly higher than the control group (P <0.05). Serum CRP was significantly associated with IL 6 (r = 0.55, P <0.01). Serum levels of CRP and IL-6 were significantly correlated with coronary artery disease scores, respectively, with correlation coefficients of 0.57 and 0.43, respectively, both P <0.01. Conclusion: Different types of CHD patients with different levels of inflammatory response, the more extensive coronary lesions, serum CRP, IL 6 levels increased, serum CRP, IL 6 may be an important risk factor for CHD