论文部分内容阅读
目的探讨老年2型糖尿病(T2DM)患者的基础-餐时胰岛素剂量。方法对169例住院老年T2DM患者,随机分每日多次皮下注射(MDI)组89例和持续皮下胰岛素输注(CSII)组80例,比较两组胰岛素量、基础量-餐前量及比例。结果血糖稳定达标后,MDI组胰岛素另为(35.88±9.54)U/d、(0.57±0.17)U·kg-1·d-1,基础量和餐前量分别占(49.70±8.69)%和(50.30±8.69)%,低血糖发生率6.47%。CSII组胰岛素量为(32.23±9.71)U/d、(0.51±0.19)U·kg-1·d-1,基础量和餐前量分别占(68.30±7.75)%和(31.70±7.75)%,低血糖发生率1.25%。两组差异显著(P<0.05)。结论老年T2DM患者CSII组比MDI组基础量显著增加,胰岛素总量减少,达到控制血糖和减少低血糖的目的。
Objective To investigate the basis of insulin resistance in patients with type 2 diabetes mellitus (T2DM) in the elderly. Methods A total of 169 elderly hospitalized patients with T2DM were randomly divided into two groups: 89 cases in subcutaneous injection (MDI) group and 80 cases in continuous subcutaneous insulin infusion (CSII) group. The levels of insulin, basal volume, . Results After the blood glucose reached the standard, the insulin content in the MDI group was (35.88 ± 9.54) U / d and (0.57 ± 0.17) U · kg-1 · d-1 respectively, and the basal and premenstrual amounts were 49.70 ± 8.69% (50.30 ± 8.69)%, the incidence of hypoglycemia was 6.47%. The amount of insulin in CSII group was (32.23 ± 9.71) U / d and (0.51 ± 0.19) U · kg-1 · d-1 respectively, and the basal and premenstrual amounts were (68.30 ± 7.75)% and (31.70 ± 7.75) , The incidence of hypoglycemia 1.25%. The difference between the two groups was significant (P <0.05). Conclusion Compared with MDI group, the basal amount of T2DM patients in CSII group increased significantly, the total amount of insulin decreased, which achieved the goal of controlling blood glucose and reducing hypoglycemia.