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目的:评价新生化片与米非司酮、甲氨喋呤三联治疗异位妊娠的临床效果与安全性,为异位妊娠临床治疗方案的制定与选择提供理论依据。方法:以我院2014年6月~2016年1月收治的82例异位妊娠患者为研究对象,根据用药方案分为研究组(n=24)和对照组(n=58),均给予甲氨蝶呤、米非司酮治疗,研究组加用新生化片治疗,持续7d。观察并比较两组患者治疗效果、β人绒毛膜促性腺激素(血β-HCG)水平变化及不良反应,评价两种治疗方案的临床效果及安全性。结果:研究组治疗成功率、治疗成功时间、包块缩小>30%率均显著高于对照组,其住院时间显著低于后者,差异有统计学意义(P<0.05)。两组患者治疗后血β-HCG均显著下降,研究组下降更为明显,且血β-HCG复常时间显著低于对照组,差异有统计学意义(P<0.05)。研究组、对照组不良反应发生率分别为16.7%、19.0%,组间比较差异无统计学意义(P>0.05)。结论:新生化片与米非司酮、甲氨蝶呤三联治疗方案能够在不增加不良反应发生率的前提下,有效提高异位妊娠的治疗成功率、缩短治疗时间,其确切的疗效及良好的安全性值得肯定,建议推广。
Objective: To evaluate the clinical effect and safety of neo-biochemical tablet combined with mifepristone and methotrexate in the treatment of ectopic pregnancy and to provide a theoretical basis for the formulation and selection of clinical treatment options for ectopic pregnancy. Methods: A total of 82 patients with ectopic pregnancy admitted from June 2014 to January 2016 in our hospital were divided into study group (n = 24) and control group (n = 58) Methotrexate, mifepristone treatment, the study group with new biochemical tablets treatment, lasted for 7 days. To observe and compare the therapeutic effects, the changes of β-human chorionic gonadotropin (β-HCG) levels and adverse reactions in both groups, and to evaluate the clinical effects and safety of the two treatment regimens. Results: The success rate of treatment, the success time of treatment and the reduction of mass in the study group were all significantly higher than those in the control group (30%). The length of stay in the study group was significantly lower than that of the control group (P <0.05). The blood β-HCG decreased significantly after treatment in both groups, the study group decreased more significantly, and the blood β-HCG recovery time was significantly lower than the control group, the difference was statistically significant (P <0.05). The incidence of adverse reactions in the study group and the control group were 16.7% and 19.0%, respectively, with no significant difference between the two groups (P> 0.05). Conclusion: The new biochemical tablet and mifepristone, methotrexate triple therapy can increase the success rate of ectopic pregnancy treatment, shorten the treatment time, the exact effect and good without increasing the incidence of adverse reactions The safety of the worthy of recognition, it is recommended to promote.