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目的研究微泡增强的超声空化阻断肿瘤微循环的可行性。方法 26只皮下VX_2肿瘤荷瘤兔随机分为超声微泡组、单纯超声组及假照组。超声微泡组经耳缘静脉推注微泡联合超声辐照肿瘤,单纯超声组以生理盐水代替微泡,假照组超声假照。各组治疗前、治疗后0、30和60min时间点对肿瘤进行超声造影,分析各时间点造影灌注峰值灰阶变化。结果超声微泡组肿瘤造影灰阶值(级)从治疗前的(67.8±13.3)级降至(29.7±20.1)级(P<0.01),维持超过60min仍无明显再通;而单纯超声组、假照组肿瘤造影灰阶值无明显变化(P>0.05)。结论微泡增强的超声空化能够有效阻断兔VX_2皮下肿瘤的微循环,其发生机制尚不清楚。
OBJECTIVE: To study the feasibility of micro-bubble enhanced ultrasonic cavitation to block tumor microcirculation. Methods Twenty - six subcutaneous VX_2 tumor bearing rabbits were randomly divided into ultrasound group, ultrasound group and sham group. Ultrasound micro-bubble group by ear vein injection of microbubbles combined with ultrasound irradiation of the tumor, simple ultrasound group instead of microvesicles with saline, sham group, according to ultrasound false illumination. Before treatment, at 0, 30, and 60 minutes after treatment, the tumor was subjected to contrast-enhanced ultrasound and the changes of peak grayscale at each time point were analyzed. Results The gray scale value of the tumor in ultrasound group decreased from (67.8 ± 13.3) to (29.7 ± 20.1) before treatment (P <0.01), and no significant recanalization occurred after more than 60 minutes of treatment. Ultrasound group , Sham group had no significant change in gray value of tumor contrast (P> 0.05). Conclusion Microbubble enhanced ultrasound cavitation can effectively block the microcirculation of rabbit VX_2 subcutaneous tumor, the mechanism of which is unclear.