早在1966年,Maki提出细菌感染在色素结石的形成机理中起关键性作用。从那时侯起,细菌感染与在东方国家经常见到的胆红素钙或郁积性色素结石同时存在的看法为大家所接受。但是,西方国家的某些结石是否由细菌引起尚有争议。最近的扫描电镜的研究表明,在色素结石和胆固醇结石的形成中细菌在结构和功能上都有明显的作用。本文作者对Johns Hopkins医院1987年8月至1988年4月间连续收治的行胆囊切除和(或)胆总管探查术的67例病人进行了结石成分分析,胆汁细菌培养,用JEOLJSM-840或JEOLJSM 35C扫描电镜的二次电子像确定细菌感染的形态学依据,用背散射电子像确定胆固醇结石中的钙盐,用 As early as 1966, Maki proposed that bacterial infections play a key role in the formation of pigmented stones. From then on, the bacterial infection was accepted by all at the same time as the common bilirubin or melanin found in oriental countries. However, it is controversial whether some of the stones in Western countries are caused by bacteria. Recent scanning electron microscopy studies have shown that the formation of pigmented stones and cholesterol stones in the structure and function of bacteria have a significant role. The authors performed a total of 67 patients undergoing cholecystectomy and / or common bile duct exploration admitted to Johns Hopkins Hospital between August 1987 and April 1988 for a total of 67 patients who underwent bile bacterial culture with JEOLJSM-840 or JEOLJSM Secondary electron images of the 35C SEM confirmed the morphological evidence of bacterial infection and used backscattered electron images to identify calcium salts in cholesterol calculus.