目的观察胃痞消对脾虚型慢性萎缩性胃炎模型大鼠肠上皮化生病理形态学的影响。方法采用N-甲基-N′-硝基-N-亚硝基胍(MNNG)饮用液自由饮用、饥饱失常、耗气泻下法复制脾虚型慢性萎缩性胃炎(CAG)大鼠模型,观察胃痞消(15,7.5,3.75 g/kg)连续灌胃给药4周后大鼠胃黏膜小肠型和大肠型上皮化生的病理学改变。结果病理学观察显示,12周后正常组大鼠无任何异常;模型组大鼠在胃黏膜萎缩基础上可见灶性不均匀的小肠型和大肠型上皮化生;胃痞消各剂量组小肠型和大肠型肠上皮化生面积有不同程度的缩小。结论胃痞消可逆转胃黏膜小肠型和大肠型肠上皮化生,具有一定抗CAG效应。 Objective To observe the effects of Weipixiao on pathomorphology of intestinal metaplasia in rat model of chronic atrophic gastritis with spleen deficiency syndrome. Methods The rat model of Chronic Atrophic Gastritis (CAG) with spleen-deficiency syndrome was prepared by freely drinking the drinking solution of N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) To observe the pathological changes of gastric mucosal small intestinal and colorectal epithelium metaplasia after Weipi consumption (15, 7.5, 3.75 g / kg) for 4 weeks. Results The pathological observation showed that there were no abnormalities in the normal group after 12 weeks. In the model group, the mucosal atrophy of the gastric mucosa was observed with small intestine and colorectal epithelial metaplasia. The small intestine type And colorectal intestinal metaplasia have different degrees of shrinkage. Conclusion Weipixiao can reverse the intestinal mucosal small intestinal and large intestine intestinal metaplasia, has a certain anti-CAG effect.