顺铂(cisplatin)在肿瘤治疗方面的重要性已逐渐被人们所认识。它所产生的毒性作用包括肾脏毒性,胃肠道毒性,骨髓抑制,神经毒性以及变态反应。顺铂的肝脏毒性很少见,在大多数病例中可见轻微而短暂的天冬氨酸转氨酶和丙氨酶转氨酶升高。白蛋白在肝脏合成,作者曾对一些接受顺铂治疗的病人进行血清白蛋白的多次检测,因而研究肝内铂水平和血清白蛋白减少之间的关系。病例和材料 The importance of cisplatin in cancer treatment has been gradually recognized by people. Its toxic effects include renal toxicity, gastrointestinal toxicity, bone marrow suppression, neurotoxicity and allergy. Cisplatin’s hepatotoxicity is rare, and mild and transient aspartate aminotransferase and alanine transaminase elevations are seen in most cases. Albumin is synthesized in the liver. The authors have performed several measurements of serum albumin in patients receiving cisplatin therapy, and therefore studied the relationship between intrahepatic platinum levels and serum albumin reduction. Cases and materials