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目的注射用七叶皂苷钠治疗口腔颌面部术后肿胀的疗效观察。方法 110例口腔颌面部术后肿胀患者,随机分为治疗组和对照组,各组55例。其中治疗组,术前1 d开始使用注射用七叶皂苷钠,20 mg加入10%葡萄糖注射液250 ml,静脉滴注,q.d.,5 d为1个疗程。对照组给予20%甘露醇250 ml静脉滴注,q.d.,5 d为1个疗程,两组患者同时给予抗感染、补液等常规基础治疗。观察两组患者术后肿胀、疼痛程度、感染和瘢痕发生率以及总有效率。结果与对照组比较,治疗组术后局部肿胀、疼痛明显减轻(P<0.05);治疗组感染和瘢痕的发生率也明显低于对照组(P<0.05);治疗组总有效率为100%,对照组总有效率为83.6%,两组差异有统计学意义(P<0.05)。结论注射用七叶皂苷钠治疗能快速消除术后水肿、减轻疼痛、预防感染、减少瘢痕发生,安全、有效,无糖皮质激素样副作用,无甘露醇反跳作用,是治疗口腔颌面部术后肿胀的有效药物。
Objective To observe the therapeutic effect of sodium aescinate on swelling of oral and maxillofacial region postoperatively. Methods A total of 110 patients with oral and maxillofacial swelling were randomly divided into treatment group and control group, with 55 cases in each group. The treatment group, preoperative 1 day began to use sodium aescinate injection, 20 mg of 10% glucose injection 250 ml, intravenous drip, q.d., 5 d for a course of treatment. Control group was given 20% mannitol 250 ml intravenous drip, q.d., 5 d for a course of treatment, both groups were given anti-infective, rehydration and other routine basic treatment. The postoperative swelling, the degree of pain, the incidence of infection and scar, and the total effective rate were observed in both groups. Results Compared with the control group, the local swelling and pain were relieved in the treatment group (P <0.05), and the incidence of infection and scar in the treatment group was also significantly lower than that of the control group (P <0.05). The total effective rate was 100% , The total effective rate of the control group was 83.6%, the difference between the two groups was statistically significant (P <0.05). Conclusion Sodium aescinate injection can quickly eliminate postoperative edema, relieve pain, prevent infection, reduce scarring, safe and effective, glucocorticoid-like side effects and no mannitol rebound, and is an effective treatment for oral and maxillofacial surgery After swelling of the effective drugs.