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片剂在溶出后才能通过生物膜进入体循环,为人体吸收并发生疗效,而崩解是溶出的前提。一般对刚生产好的片剂均需测定崩解剂对溶出速度的影响,即测定片剂的溶出度。但经贮存后的影响则研究很少,本文就几种新型崩解剂(乙醇淀粉钠、聚维酮,交联羧甲纤维素)对直接压制片经30℃贮存14个月后的溶出度影响进行评价。实验结果与讨论:制备30种片剂,每种片剂内含1%对氨基苯甲酸、2%新型崩解
After the dissolution of the tablet through the biofilm into the systemic circulation for the body to absorb and take effect, and disintegration is the premise of dissolution. General newly produced tablets are required to determine the effect of disintegrant on the dissolution rate, that is measured tablet dissolution. However, the effect after storage is rarely studied. In this paper, several new disintegrants (sodium starch glycolate, povidone and croscarmellose) were tested for their dissolution after direct storage at 30 ℃ for 14 months Impact assessment. EXPERIMENTAL RESULTS AND DISCUSSION: Thirty tablets were prepared, each containing 1% para-aminobenzoic acid, 2% new disintegration