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目的评价交警多环芳烃(PAHs)暴露的肺癌发生风险。方法通过检测交警及其对照人群尿中1-羟基芘(1-OHP)含量和血清癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)、细胞角质蛋白19片段(CYFRA21-1)水平,分析1-OHP与CEA、NSE、CYFRA21-1之间的相关关系;通过尿1-OHP浓度来预估多环芳烃暴露人群肺癌的死亡增加风险。结果 63名交警尿中1-OHP浓度(2.0μmol/mol Cr)明显高于其对照人群(1.1μmol/mol Cr),尿1-OHP浓度≥2.3μmol/mol Cr的交警与对照的构成比分别为34.29%与14.29%。交警血清CEA、NSE和CYFRA21-1含量也明显高于对照,分别为14.20ng/ml与11.44ng/ml,9.38ng/ml与7.73ng/ml,0.99ng/ml与0.73ng/ml(P<0.05)。尿1-OHP的对数浓度(In[1-OHP])分别与血CEA、NSE和CYFRA21-1含量的Pearson相关分析表明,它们之间存在明显的正相关关系(r=0.3862～0.4826,P<0.05)。通过交警与对照人群尿1-OHP浓度预估其苯并[a]芘(BaP)暴露的肺癌死亡率分别为157/10万与82/10万,14种PAHs暴露的肺癌死亡率分别为248/10万与132/10万。结论多环芳烃暴露可能增加肺癌的发生风险。
Objective To evaluate the risk of lung cancer exposed by traffic police polycyclic aromatic hydrocarbons (PAHs). Methods The levels of urinary 1-hydroxypyrene (1-OHP), serum CEA, NSE, CYFRA21-1 in the traffic police and its control group were detected. Level, the correlation between 1-OHP and CEA, NSE and CYFRA21-1 was analyzed. The risk of lung cancer death was estimated by urinary 1-OHP concentration. Results The urinary concentrations of 1-OHP (2.0μmol / mol Cr) in 63 traffic police officers were significantly higher than those in the control subjects (1.1μmol / mol Cr) and the urinary 1-OHP concentrations ≥2.3μmol / 34.29% and 14.29% respectively. The contents of CEA, NSE and CYFRA21-1 in traffic policemen were also significantly higher than those of the control group (14.20ng / ml and 11.44ng / ml, 9.38ng / ml and 7.73ng / ml, 0.99ng / ml and 0.73ng / ml respectively 0.05). Pearson correlation analysis of logarithmic concentration of urinary 1-OHP (In [1-OHP]) and blood CEA, NSE and CYFRA21-1 showed that there was a significant positive correlation between them (r = 0.3862-0.4826, P <0.05). The mortality rates of lung cancer from exposure to benzo [a] pyrene (BaP) exposure to urinary 1-OHP concentrations in traffic police and control population were 157 / 10,000 and 82 / 100,000, respectively. The mortality rates of lung cancer exposed by 14 PAHs were 248 / 100,000 and 132 / 100,000. Conclusions PAH exposure may increase the risk of lung cancer.