过去一直认为神经元处于一种有丝分裂后的终末分化状态,但最近有许多资料表明成熟神经元可以重新进入细胞周期。然而,神经元的细胞周期激活机制尚不清楚。对于神经元而言,细胞周期机制是应对DNA损伤的一个重要组成部分,再进入细胞周期是为了修复DNA损伤,如损伤太重无法修复则诱导细胞凋亡。 In the past, neurons were thought to be in an end-stage state of mitosis, but more recent data suggest that mature neurons can re-enter the cell cycle. However, the mechanism of cell cycle activation in neurons is unclear. For neurons, the cell cycle mechanism is an important part of dealing with DNA damage, reentry into the cell cycle to repair DNA damage, and to induce apoptosis if damage is too severe to repair.