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目的探讨艾滋病病毒(HIV)感染者/艾滋病(AIDS)病人在应用D4T+3TC+NVP抗病毒治疗方案后,对美沙酮维持治疗剂量的影响,为在美沙酮门诊开展抗病毒治疗方案选择及美沙酮剂量的调整提供依据。方法对观察组、对照组1、3、6个月服用美沙酮剂量的变化情况进行对比分析,所有数据用SPSS 13.0进行统计分析。结果观察组13例服用D4T+3TC+NVP抗病毒治疗的美沙酮维持治疗者,对照组18例未行抗病毒治疗的美沙酮维持治疗者,观察结果显示,观察组6个月后美沙酮维持治疗量平均增加40.78mg。D4T+3TC+NVP抗病毒治疗对美沙酮维持治疗剂量的差异,有显著的统计学意义(χ2=49.92,P<0.01)。结论在美沙酮门诊就治的HIV感染者/AIDS病人中开展抗病毒治疗,要及时考虑选择抗病毒治疗的方案和及时调整美沙酮维持治疗的剂量。
Objective To investigate the effects of D4T + 3TC + NVP antiviral therapy on the dose of methadone maintenance therapy in HIV / AIDS patients. To explore the choice of antiretroviral therapy regimens and the dose of methadone in methadone clinics Adjust to provide basis. Methods The changes of the dose of methadone in observation group and control group for 1, 3 and 6 months were compared and analyzed. All the data were analyzed by SPSS 13.0. Results In the observation group, 13 patients treated with D4T + 3TC + NVP antiviral therapy and 18 patients treated with methadone without antiviral therapy in the control group showed that in the observation group, the average amount of methadone maintenance treatment after 6 months Increase 40.78mg. D4T + 3TC + NVP antiviral treatment of methadone maintenance dose differences were statistically significant (χ2 = 49.92, P <0.01). Conclusions Antiviral treatment of HIV infected patients / AIDS patients treated in methadone clinics should promptly consider the choice of antiretroviral therapy and timely adjust the dose of methadone maintenance treatment.