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本研究采用精氨酰-甘氨酰-天冬氨酸（Arg-Cly-，RGD）序列肽精氨酰-甘氨酰-天冬氨酰-丝氨酸四肽（Arg-Gly－Asp－Ser，RGDS），观察其对血小板聚集功能、实验性血栓形成以及对纤维蛋白溶解系统的影响。结果表明RGDS显著抑制了血小板聚集功能，一分钟聚集抑制率、最大聚集抑制率均随药物体外作用浓度增加而增加（0．05－1．0mmol／L），同时聚集速率显著下降。体内给予RGDS（8μmol/kg体重）能显著抑制颈总动脉旁路血栓形成，抑制率达到51%（P＜0．001），但此浓度对纤溶活性指标无影响。
In this study, Arg-Gly-Asp-Ser (Arg-Cly-, RGD) RGDS) to observe its effect on platelet aggregation, experimental thrombosis and fibrinolytic system. The results showed that RGDS significantly inhibited the function of platelet aggregation, one-minute aggregation inhibition rate and maximum aggregation inhibition rate increased with the increase of drug concentration in vitro (0.05-1.0 mmol / L), meanwhile the aggregation rate decreased significantly. In vivo administration of RGDS (8 μmol / kg body weight) significantly inhibited carotid artery bypass thrombosis with a 51% inhibition rate (P <0.001), but this concentration had no effect on fibrinolytic activity.