抗病毒药物研究始于五十年代初期。当时发现美替沙腙(Methisazone)对小鼠牛痘感染有活性,在临床上证实它对天花有防治效果。这个发现提示了病毒感染疾病的化学防治是可能的。由于病毒的生长繁殖与宿主代谢密切相关。作用于病毒的药物不可避免地也损伤宿主细胞。因此,寻找安全有效的抗病毒药物是一项艰巨的任务。近十年来,人们以疱疹病毒和流感病毒为突破口,找到了多种具有良好选择性的抗病毒药物。临床上 Antiviral drug research began in the early 1950s. Methisazone was found to be active against mouse vaccinia and was clinically proven to be effective in controlling smallpox. This finding suggests that chemical control of virus-infected diseases is possible. Due to the virus’s growth and reproduction and host metabolism are closely related. Drugs that act on the virus inevitably also damage the host cell. Therefore, finding safe and effective antiviral drugs is a daunting task. In the past ten years, people have made breakthroughs in the herpes virus and influenza virus and found many kinds of antiviral drugs with good selectivity. Clinically