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长期以来,心肌细胞被认为是类似神经细胞,均属高度分化的细胞。当它受损后,多数学者均认为缺乏再生能力。特别是人类的心肌细胞更是如此。但自本世纪以来,人们已观察到实验动物的受损心肌是具有一定再生能力的。后来,又发现人类婴幼儿和儿童的心肌在受损后亦有再生能力,如MacMahon等早就提到白喉性心肌炎的患儿,其心肌细胞有再生能力。但也有一些学者始终对人类心肌的再生能力,持怀疑的态度。本文作者,在各类型心肌梗塞所致死亡的66例中,发现39例心肌细胞具有不同程度的再生表现,检出率达59.09％,且观察到心肌再生能力并不受性别和年龄的影响。这就回答了心肌梗塞受损后有无再生能力的问题。因此,这项研究工作是有成绩和价值的。在临床上,对心肌梗塞患者,如能尽早抢救,除可缩小心肌梗塞的范围和减少、减轻心肌的损伤外,从理论上来说,心肌再生能力也将会更加完全。 相信今后此项研究工作还会不断深入,如利用电镜等先进检查手段,有可能获得更加完善的资料,从而进一步提高这项研究的科学价值。
For a long time, myocardial cells are considered similar to nerve cells, are highly differentiated cells. When it is damaged, most scholars believe that the lack of regeneration. Especially in human cardiomyocytes is even more so. However, since the beginning of this century, it has been observed that the damaged myocardium of experimental animals has a certain regenerative ability. Later, it was found that human infants and children’s myocardium also has a regenerative capacity after being damaged. For example, MacMahon et al. Have mentioned that children with diphtheria myocarditis have regenerative capacity of cardiomyocytes. However, some scholars have always been skeptical about the regenerative capacity of human myocardium. The authors of this study found that 39 cases of cardiomyocytes had different degree of regeneration in 66 cases of various types of death caused by myocardial infarction. The detection rate was 59.09%. And the ability of myocardial regeneration was not affected by gender and age. This answers the question of whether there is a regenerative capacity after a myocardial infarction is damaged. Therefore, the research work has achievements and value. Clinically, patients with myocardial infarction, such as early rescue, in addition to narrowing the scope and reduce myocardial infarction, reduce myocardial damage, in theory, the ability of myocardial regeneration will also be more complete. I believe the future of this research will continue to deepen, such as the use of advanced inspection methods such as electron microscopy, it is possible to obtain more complete information to further enhance the scientific value of this study.