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目的:探讨小剂量阿替普酶溶栓治疗老年急性次大面积肺栓塞的临床疗效。方法:将我院2012年1月-2014年6月间收治的急性次大面积肺栓塞老年患者50例随机分为对照组(n=25)和实验组(n=25),对照组予低分子肝素和华法林抗凝治疗,实验组在对照组的基础上给予小剂量阿替普酶静脉泵入,14 d后比较两组患者治疗前后的动脉血气分析指标、右心功能和临床有效率。结果:实验组治疗后的动脉血气分析指标、右心功能及临床有效率均显著优于对照组(P<0.05)。结论:应用小剂量阿替普酶溶栓治疗老年急性次大面积肺栓塞安全有效。
Objective: To investigate the clinical efficacy of low-dose alteplase thrombolysis in the treatment of acute sub-acute pulmonary embolism in the elderly. Methods: A total of 50 elderly patients with acute sub-large pulmonary embolism who were admitted to our hospital from January 2012 to June 2014 were randomly divided into control group (n = 25) and experimental group (n = 25) Heparin and warfarin anticoagulant therapy were used. The experimental group was given intravenous infusion of low-dose alteplase on the basis of the control group. Arterial blood gas analysis, right heart function and clinical efficiency were compared between the two groups before and after treatment for 14 days. Results: The arterial blood gas analysis index, right heart function and clinical effective rate in the experimental group were significantly better than those in the control group (P <0.05). Conclusion: It is safe and effective to treat acute sub-acute large-area pulmonary embolism with small-dose alteplase thrombolysis.