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目的 探讨近10年新疆地区宫颈癌患者在发病年龄上的趋势以及年轻宫颈癌患者在临床、病理组织学等方面的特点,为目前宫颈癌的防治提供理论依据.方法 对新疆维吾尔自治区人民医院妇科病区从2005G1-2014G12所收治的1004例浸润性宫颈癌患者的年龄、临床分期、是否存在HPV感染以及病理组织学类型等资料进行回顾性分析.结果近10年来宫颈癌患者的平均发病年龄降低,从2005~2009年的5485±857岁降低至2010~2014年的4686±682岁;年轻宫颈癌(≤35岁)患者的构成比升高,从2005~2009年的9位(280%)上升至2010~2014年的56位(820%),而且临床治疗的早期(Ⅰ~Ⅱ)宫颈癌患者比例所有升高,其中Ⅰ期由2565%升至为4237%.与此同时,宫颈鳞状细胞癌在不同年龄组患者中均为主要的病理类型,宫颈腺癌次之,但年轻宫颈癌患者(≤35岁)中非鳞癌的比例较之其他年龄组明显升高(P<001).在HPV16/18型感染方面,年轻宫颈癌患者(≤35岁)其感染阳性率最高,达9538%;老年组宫颈癌患者阳性率为8660%居第二位.结论 近10年新疆地区宫颈癌患者年轻化的发病趋势愈加明显,年轻的宫颈癌患者呈现出临床期别较早、HPV16/18型感染率较高以及非鳞癌比例高的临床特点.在日常工作中要重视在年轻群体中加强对宫颈疾病的筛查和提高群体认知程度,争取达到早诊、早治,从而进一步降低宫颈癌的发生.
Objective To explore the trend of age at onset of cervical cancer in Xinjiang area in recent 10 years and the characteristics of young patients with cervical cancer in clinical and histopathological aspects and to provide a theoretical basis for the prevention and treatment of cervical cancer.Methods The gynecology of Xinjiang Uygur Autonomous Region People’s Hospital Ward from 2005G1-2014G12 of 1004 cases of invasive cervical cancer patients with age, clinical stage, the presence of HPV infection and histopathological types of data were retrospectively analyzed.Results Cervical cancer in patients over the past 10 years, the average age of onset decreased , From 5485 ± 857 years in 2005 ~ 2009 to 4686 ± 682 years in 2010 ~ 2014. The proportion of young patients with cervical cancer (≤35 years old) increased from 9 (280%) in 2005 ~ 2009, (820%) from 2010 to 2014, and the proportion of patients with cervical cancer in the early stage of clinical treatment (Ⅰ ~ Ⅱ) all increased, of which stage Ⅰ increased from 2565% to 4237% .At the same time, cervical squamous cell carcinoma Astrocytoma is the main pathological type in different age groups, followed by cervical adenocarcinoma, but the proportion of non-squamous cell carcinoma in young patients with cervical cancer (≤35 years) is significantly higher than that in other age groups (P <0.001) In HPV16 / 18 infection, year Cervical cancer patients (≤35 years old) had the highest positive rate of infection (9538%), and the positive rate of cervical cancer patients was the second highest in elderly group (8660%) .Conclusion The incidence of cervical cancer patients in Xinjiang region in recent 10 years is more and more obvious, Young patients with cervical cancer showed an earlier clinical stage, HPV16 / 18 infection rate and the high proportion of non-squamous cell carcinoma clinical features in the daily work should pay attention to young people in the strengthening of screening and improvement of cervical disease Group awareness, strive to achieve early diagnosis, early treatment, thereby further reducing the incidence of cervical cancer.