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198 0年 ,Furchgott和 Zawadzki等在研究一些血管扩张剂 ,如硝普钠、乙酰胆碱和缓激肽作用于血管内皮细胞的实验中 ,发现内皮细胞可释放出一种称之为内皮源性舒张因子 (EDRF) ,引起血管平滑肌松弛而扩张。 1987年 Palmer和 Moncada等通过药理学、生物化学以及形态学方法证明了
In 198, Furchgott and Zawadzki et al., In their experiments on the effects of some vasodilators such as sodium nitroprusside, acetylcholine and bradykinin on vascular endothelial cells, found that endothelial cells release an enzyme called endothelium-derived relaxing factor ( EDRF), causing vascular smooth muscle relaxation and expansion. In 1987 Palmer and Moncada and other pharmacological, biochemical and morphological methods proved