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缺血修饰白蛋白(IMA)是近年来发现的在急性冠状动脉综合征的早期即可出现的血清标志物。进一步的研究证实IMA是心肌缺血标志物而非心肌损伤标志物,在急诊胸痛患者的危险分层预后评估中具有重要意义。然而,IMA并非急性冠状动脉综合征所特有的标志物,在急性脑卒中、肺梗死、难产、慢性肾性贫血患者甚至正常妊娠妇女中均发现可以升高。本文综述了IMA在各种疾病时的表现及对IMA结果的校正,以便更客观地认识IMA。
Ischemia-modified albumin (IMA) is a serum marker found in recent years that occurs early in acute coronary syndrome. Further studies confirm that IMA is a marker of myocardial ischemia, not a marker of myocardial damage, and is of great importance in the assessment of risk stratification in patients with acute chest pain. However, IMA is not a unique marker of acute coronary syndrome and is found elevated in patients with acute stroke, pulmonary infarction, dystocia, chronic renal anemia and even normal pregnant women. This article reviews the performance of IMA in various diseases and the correction of the IMA results so that IMA can be more objectively understood.