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帕金森病(PD)是一种常见于中老年人的进行性神经系统变性疾病,其病理特征是黑质多巴胺能神经元变性缺失。PD的确切病因和发病机制尚未明确,在家族性PD患者中发现该病与α-突触核蛋白(α-synuclein)基因、Parkin基因等突变有关,而在散发性PD患者中发现黑质的生化病理改变与环境?
Parkinson’s disease (PD) is a progressive neurodegenerative disease common in the elderly and is characterized by a lack of degeneration of substantia nigra dopaminergic neurons. The exact etiology and pathogenesis of PD are not yet clear. It is found in familial PD patients that the disease is associated with mutations such as α-synuclein gene and Parkin gene. In patients with sporadic PD, the substantia nigra Biochemical and pathological changes and the environment?